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HLA "potential" incompatible

Hi all, I have a kidney donor and we have been cleared/matched for transplant later this year.  Coordinator called and stated that I have 2 "potential" antibodies to donors antigens, and that I should go NOW with tx instead of waiting because I could develop antibodies and then could NOT do the tx.  I am confused, please send any information, as I am thinking if I develop these won't I reject down the road?? any info, articles, etc appreciated. J. 

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  • Hi Jane,

    I had a HLA incompatible transplant. A class 2 antigen was removed by plasmapheresis. I am now 18 months post transplant and doing fine.

    Let me know if you have any further questions



    • Thank you Nipun for your reply.  I do not have incompatible (at this point) they are calling two of the antibodies "potential" (could develop into incompatible).  So I am scheduled to have tx in 3 weeks. Question, for your antirejection meds, are you on the "normal" dose most transplant patients take? Also, how are these meds affecting your body? Any side effects or problems? Thanks so much.  Jane

      • Hi Jane

        Yes, I am on a normal dosage which are as below:-

        Prograf: 1/.5 mg (Tacrolimus Level - 6)

        Cellcept: 750/500 mg

        Omnacortil (prednisolone) - 5 mg

        My creatnine level is now stable at 1.3. The medicine dosage varies from person to person.

        I underwent kidney transplant post 3 sessions of plasmapheresis. Also, I was monitored twice for the antigen count and was discharged on sixth day post transplant.  I do not have any side affects as of now.

        In your case the doctors will also monitor the antigen count through a simple blood test. Have faith on your transplant team.

        All the very best for your surgery



  • Hi Jane,

    After a Tx, you will be immunosuppressed and the medications you take should prevent the development of any new antibodies.  These powerful meds keep the immune system from "finding" the Tx organ.  I added  a link to the National Kidney Foundation site to help answer some questions.  You can always ask your friends here about any other issues.  Good luck!

    NKF info

    • Thank you kidney boy. This is a great place to get feedback from people who have. " been there..."
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