I am 3-year post liver TX. For the last 2 1/2 years I been taking 2mg of Prograf @ twice per day, plus Myfortic, and Prednisone. In the last 6-months I have been reducing Prednisone from 5mg/day to most recently none.Over this same time frame my Tac trough has elevated from a steady 5 to 7 Tac level to between 8 to 14. The most recent Tac trough was 10.1. As result, the docs are cutting my Prograf in half to only 1 mg @ twice per day.
I'm well aware of the "toxic" kidney affects of an elevated trough level s reducing it is good.
My only question: For those of yoiu on the same or similar med regimen for liver TX, is a graudally increasing Tac trough level a few years post liver TX "normal" or could it be related to the Prednisone reduction?