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A P/C Spot Urine Sample analysis is a tool which is used to judge overall kidney function and predict kidney issues.    

*"Normal individuals usually excrete very small amounts of protein in the urine. Persistently increased protein excretion is usually a marker of kidney damage. The excretion of specific types of protein, such as albumin or low molecular weight globulins, depends on the type of kidney disease that is present. Increased excretion of albumin is a sensitive marker for chronic kidney disease due to diabetes, glomerular disease, and hypertension. Increased excretion of low molecular weight globulins is a sensitive marker for some types of tubulointerstitial disease. In this guideline, the term “proteinuria” refers to increased urinary excretion of albumin, other specific proteins, or total protein; “albuminuria” refers specifically to increased urinary excretion of albumin. “Microalbuminuria” refers to albumin excretion above the normal range but below the level of detection by tests for total protein. Guidelines for detection and monitoring of proteinuria in adults and children differ because of differences in the prevalence and type of chronic kidney disease."

Creatinine is a protein, the result of muscle activity and is normally filtered out by the kidneys. Levels are affected by increased muscle activity, diet (meat consumption,) hydration (dilution), and medication (especially immuno-supressant meds) and is used as a tool to interpret kidney function. Albumin is a protein that your body uses for cell growth and to help repair tissues. It’s normally present in the blood. A certain level of it in your urine may be a sign of kidney damage. The results of a Protein-Creatinine spot urine sample is a ratio between Creatinine to Albumin, reported as a percentage. This test is performed as a "first in the morning" urination collection and is seen as a possible alternative to 24 hour collection.

A person with normally function kidneys will have a P/C level between 5 to 23 range. A transplant patient with a level above that might be subject to increased monitoring or investigation, more frequent spot testing and a biopsy if warranted. Use of these tests are becoming more common and may become part of the routine for kidney transplant patients.

NKF info *

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